کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
334483 546559 2012 4 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Schizotypy trait and striatal dopamine receptors in healthy volunteers
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Schizotypy trait and striatal dopamine receptors in healthy volunteers
چکیده انگلیسی

Individuals with schizotypal features exhibit cognitive, perceptual and social deficits that are similar to but less prominent than those seen in patients with schizophrenia. Dopaminergic hyperactivity in the striatum has been related to the positive symptoms of schizophrenia, and brain-imaging studies of dopamine uptake in the striatum are thought to be linked to the pathophysiological mechanisms underlying schizophrenia. The aim of this study was to investigate whether the increased availability of striatal dopamine (DA) D2/3 receptors is related to elevated levels of schizotypal features in healthy individuals. The Schizotypal Personality Questionnaire (SPQ) was administered to 55 healthy volunteers. The availability of their striatal DA D2/3 receptors was analysed using [123I] iodobenzamide single photon emission computed tomography (SPECT). Although the SPQ total scores showed no correlation with the availability of total (left and right) striatal DA D2 receptors, the SPQ disorganised subscale scores were positively correlated with the availability of right striatal DA D2/3 receptors. Our findings demonstrated that the availability of striatal DA D2/3 receptors may be associated with schizotypal features in healthy volunteers.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychiatry Research: Neuroimaging - Volume 201, Issue 3, 31 March 2012, Pages 218–221
نویسندگان
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