کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3347047 1215932 2014 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Local delivery of linezolid from poly-d,l-lactide (PDLLA)–linezolid–coated orthopaedic implants to prevent MRSA mediated post-arthroplasty infections
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Local delivery of linezolid from poly-d,l-lactide (PDLLA)–linezolid–coated orthopaedic implants to prevent MRSA mediated post-arthroplasty infections
چکیده انگلیسی

The present study focuses on the use of linezolid as local delivery agent for direct administration of the drug at the orthopaedic implant site. Local drug delivery system with linezolid added to the Poly D, L-(Lactide) polymer solution was used to coat the orthopaedic grade K-wires. Bacterial adherence on K-wires was then determined to evaluate the effect of the coated drug on the adherence of MRSA. A significant decrease in bacterial adherence as compared to naked wires was observed on all the coated K-wires (2.5, 5 and 10% w/w linezolid coated) with maximum decrease of 60%. This represents an aggressive early approach to prevent initial adherence of bacterial population. With the rise in MRSA mediated orthopaedic device related infections, the use of linezolid loaded polymer coated implants is definitely an attractive strategy against drug resistant strains of S. aureus.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Diagnostic Microbiology and Infectious Disease - Volume 79, Issue 3, July 2014, Pages 387–392
نویسندگان
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