کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3360004 1591841 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rifampicin combined regimens for Gram-negative infections: data from the literature
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروبیولوژی و بیوتکنولوژی کاربردی
پیش نمایش صفحه اول مقاله
Rifampicin combined regimens for Gram-negative infections: data from the literature
چکیده انگلیسی

Multidrug-resistant (MDR) Gram-negative bacterial infections are associated with high morbidity and mortality. Given the lack of availability of new highly effective antimicrobial drugs against multiresistant strains, combination regimens are administered that include rifampicin for its demonstrated in vitro synergism with multiple drugs. A literature review was performed of clinical studies reporting the use of rifampicin in the treatment of MDR Gram-negative bacterial infections. Nineteen studies were found, including only one randomised controlled study. Data in the literature on combined therapeutic regimens with rifampicin are limited and refer mostly to uncontrolled studies. Therefore, the real clinical benefit of using rifampicin-containing therapies for the treatment of Gram-negative multiresistant bacteria in terms of clinical outcome and survival rates still needs to be assessed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Antimicrobial Agents - Volume 35, Issue 1, January 2010, Pages 39–44
نویسندگان
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