Prophylaxis of Infective Endocarditis: Prevention of the Perfect Storm

Despite the availability of endocarditis prophylaxis guidelines for more than five decades, no prospective, randomised trial has ever been conducted to evaluate the efficacy and safety of this practice. This fact, in combination with mixed results from case-control investigations and other factors, has prompted a re-evaluation of the appropriateness of the guidelines. The update provided herein highlights recent revisions in guidelines promulgated by different countries.