کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3398820 1222339 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی میکروب شناسی
پیش نمایش صفحه اول مقاله
Carbapenem resistance in Acinetobacter baumannii: mechanisms and epidemiology
چکیده انگلیسی

ABSTRACTThe increasing trend of carbapenem resistance in Acinetobacter baumannii worldwide is a concern since it limits drastically the range of therapeutic alternatives. Metallo-β-lactamases (VIM, IMP, SIM) have been reported worldwide, especially in Asia and western Europe, and confer resistance to all β-lactams except aztreonam. The most widespread β-lactamases with carbapenemase activity in A. baumannii are carbapenem-hydrolysing class D β-lactamases (CHDLs) that are mostly specific for this species. These enzymes belong to three unrelated groups of clavulanic acid-resistant β-lactamases, represented by OXA-23, OXA-24 and OXA-58, that can be either plasmid- or chromosomally-encoded. A. baumannii also possesses an intrinsic carbapenem-hydrolysing oxacillinase, the expression of which may vary, that may play a role in carbapenem resistance. In addition to β-lactamases, carbapenem resistance in A. baumannii may also result from porin or penicillin-binding protein modifications. Several porins, including the 33-kDa CarO protein, that constitute a pore channel for influx of carbapenems, might be involved in carbapenem resistance.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Clinical Microbiology and Infection - Volume 12, Issue 9, September 2006, Pages 826–836
نویسندگان
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