کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3422909 1226959 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A worm of one's own: how helminths modulate host adipose tissue function and metabolism
ترجمه فارسی عنوان
یک کرم از خود: چگونه کلیه ها می تواند عملکرد بافت چربی میزبان و متابولیسم
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی انگل شناسی
چکیده انگلیسی


• Type 2 immune cells are present in healthy adipose tissue and decline with obesity.
• Type 2 immune cells can promote white adipose tissue beiging.
• Helminths promote adipose tissue type 2 immunity and improve metabolic homeostasis.

Parasitic helminths have coexisted with human beings throughout time. Success in eradicating helminths has limited helminth-induced morbidity and mortality but is also correlated with increasing rates of ‘western’ diseases, including metabolic syndrome and type 2 diabetes. Recent studies in mice describe how type 2 immune cells, traditionally associated with helminth infection, maintain adipose tissue homeostasis and promote adipose tissue beiging, protecting against obesity and metabolic dysfunction. Here, we review these studies and discuss how helminths and helminth-derived molecules may modulate these physiologic pathways to improve metabolic functions in specific tissues, such as adipose and liver, as well as at the whole-organism level.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 31, Issue 9, September 2015, Pages 435–441
نویسندگان
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