کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3426115 | 1227316 | 2008 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Autophagic machinery activated by dengue virus enhances virus replication
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
ایمنی شناسی و میکروب شناسی
ویروس شناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Autophagy is a cellular response against stresses which include the infection of viruses and bacteria. We unravel that Dengue virus-2 (DV2) can trigger autophagic process in various infected cell lines demonstrated by GFP-LC3 dot formation and increased LC3-II formation. Autophagosome formation was also observed under the transmission electron microscope. DV2-induced autophagy further enhances the titers of extracellular and intracellular viruses indicating that autophagy can promote viral replication in the infected cells. Moreover, our data show that ATG5 protein is required to execute DV2-induced autophagy. All together, we are the first to demonstrate that DV can activate autophagic machinery that is favorable for viral replication.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Virology - Volume 374, Issue 2, 10 May 2008, Pages 240–248
Journal: Virology - Volume 374, Issue 2, 10 May 2008, Pages 240–248
نویسندگان
Ying-Ray Lee, Huan-Yao Lei, Ming-Tao Liu, Jen-Ren Wang, Shun-Hua Chen, Ya-Fen Jiang-Shieh, Yee-Shin Lin, Trai-Ming Yeh, Ching-Chuan Liu, Hsiao-Sheng Liu,