کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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3921393 | 1599893 | 2007 | 4 صفحه PDF | دانلود رایگان |
ObjectivesTo compare early loss rates between twin and singleton pregnancies following ART.Study designFirst-trimester sonography counted the number of embryos with positive heartbeat in women undergoing IVF/ICSI and transfer of one to three embryos. The number of lost pregnancies was calculated from a second-trimester sonogram. Loss rates of the entire pregnancy were related to maternal age <38 or ≥38 years, IVF or ICSI, and cleavage or blastocyst stage embryo transfers (in ICSI cases).ResultsPatients underwent IVF with (n = 672) and without (n = 189) ICSI. The overall odds of miscarrying the entire singleton pregnancy were 2.6 times that of a twin gestation (95% CI 1.5, 4.5). The disadvantage for singletons compared to twins seems more apparent in pregnancy after ICSI in the subgroup of patients <38 years (OR 2.9, 95% CI 1.5, 5.8). In this subgroup, the disadvantage conferred to singletons appeared only among days 2–3 embryo transfers (OR 3.0, 95% CI 1.3, 7.2).ConclusionA significantly lower early spontaneous loss rate of twin pregnancies seems related to ICSI followed by cleavage stage embryo transfer in patients <38 years.
Journal: European Journal of Obstetrics & Gynecology and Reproductive Biology - Volume 130, Issue 2, February 2007, Pages 212–215