کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3924368 1253101 2015 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Survival and Functional Stability in Chronic Kidney Disease Due to Surgical Removal of Nephrons: Importance of the New Baseline Glomerular Filtration Rate
ترجمه فارسی عنوان
بقا و پایداری عملکرد در بیماری مزمن کلیه به علت حذف جراحی نرون ها: اهمیت نرخ جدید فیلتراسیون گلومرولی
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

BackgroundChronic kidney disease (CKD) can be associated with a higher risk of progression to end-stage renal disease and mortality, but the etiology of nephron loss may modify this. Previous studies suggested that CKD primarily due to surgical removal of nephrons (CKD-S) may be more stable and associated with better survival than CKD due to medical causes (CKD-M).ObjectiveWe addressed limitations of our previous work with comprehensive control for confounding factors, differentiation of non–renal cancer-related mortality, and longer follow-up for more discriminatory assessment of the impact of CKD-S.Design, setting, and participantsFrom 1999 to 2008, 4299 patients underwent surgery for renal cancer at a single institution. The median follow-up was 9.4 yr (7.3–11.0). The new baseline glomerular filtration rate (GFR) was defined as the highest GFR between the nadir and 42 d after surgery. Three cohorts were retrospectively evaluated: no CKD (new baseline GFR >60 ml/min/1.73 m2); CKD-S (new baseline GFR<60 but preoperative >60 ml/min/1.73 m2); and CKD-M/S (new baseline and preoperative GFR both <60 ml/min/1.73 m2). Cohort status was permanently set at 42 d after surgery.InterventionRenal surgery.Outcome measurements and statistical analysisDecline in renal function (50% reduction in GFR or dialysis), all-cause mortality, and non–renal cancer mortality were examined using a multivariable Cox proportional hazards model.Results and limitationsCKD-M/S had a higher incidence of relevant comorbidities and the new baseline GFR was lower. On multivariable analysis (controlling for age, gender, race, diabetes, hypertension, and cardiac disease), CKD-M/S had higher rates of progressive decline in renal function, all-cause mortality, and non–renal cancer mortality when compared to CKD-S and no CKD (hazard ratio [HR] 1.69–2.33, all p < 0.05). All-cause mortality was modestly higher for CKD-S than for no CKD (HR 1.19, p = 0.030), but renal stability and non–renal cancer mortality were similar for these groups. New baseline GFR of <45 ml/min/1.73 m2 significantly predicted adverse outcomes. The main limitation is the retrospective design.ConclusionsCKD-S is more stable than CKD-M/S and has better survival, approximating that for no CKD. However, if the new baseline GFR is <45 ml/min/1.73 m2, the risks of functional decline and mortality increase. These findings may influence counseling for patients with localized renal cell carcinoma and higher oncologic potential when a normal contralateral kidney is present.Patient summarySurvival is better for surgically induced chronic kidney disease (CKD) than for medically induced CKD, particularly if the postoperative glomerular filtration rate is ≥45 ml/min/1.73 m2. Patients with preexisting CKD are at risk of a significant decline in kidney function after surgery, and kidney-preserving treatment should be strongly considered in such cases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: European Urology - Volume 68, Issue 6, December 2015, Pages 996–1003
نویسندگان
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