کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3945383 1254265 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Improved outcomes with dose-dense paclitaxel-based neoadjuvant chemotherapy in advanced epithelial ovarian carcinoma
ترجمه فارسی عنوان
نتایج بهبود یافته با شیمیدرمانی نئوئیدوانانت مبتنی بر پلاکتکسل با دوز بالا در کارسینوم تخمدان پیشرفته اپیتلیال
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


• Neoadjuvant DDP is a novel therapy for epithelial ovarian cancer.
• Only 14% of DDP patients required conversion to standard taxane due to toxicity.
• pCR and NRD rates at time of interval debulking surgery were higher with DDP.

ObjectiveWe compared tolerability, toxicity, response, and interval debulking surgery (IDS) outcomes between patients who received weekly dose-dense paclitaxel (DDP) and every three-week platinum to standard every three-week taxane plus platinum neoadjuvant chemotherapy (NACT) for advanced epithelial ovarian cancer (EOC).MethodsWe conducted a retrospective study of patients receiving NACT at our center between June 1, 2012 and July 31, 2015. Patients with stage III/IV EOC who received at least one cycle of DDP (weekly paclitaxel plus every three-week carboplatin) or standard taxane (every three-week paclitaxel or docetaxel plus carboplatin) therapy were included. Abstracted data included demographics, tolerability, grade 3/4 toxicity, response, and IDS outcomes. Fisher's exact and student t-test were used for statistical significance.ResultsTwenty-one patients received DDP and 40 received standard taxane. Tolerability was comparable. More patients receiving DDP experienced grade 3 or 4 toxicity when considered in aggregate (86% vs. 40%; p = 0.001). Pathologic complete response (pCR) was achieved in 14% of DDP patients versus 3% of standard (p = 0.11). 48% of patients in the DDP group were debulked to no residual disease (NRD) versus 28% in the standard group (p = 0.16).ConclusionsWhile associated with an increase in severe toxicity compared to standard three-week taxane, DDP appears to facilitate higher rates of pCR and NRD for patients receiving NACT in this preliminary study. These results warrant further investigation of DDP for patients with advanced EOC and assessment of impact on long-term survival outcomes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 142, Issue 1, July 2016, Pages 25–29
نویسندگان
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