کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3945391 1254265 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Clinicopathologic characteristics and survival of patients with gynecologic malignancies metastatic to the brain
ترجمه فارسی عنوان
ویژگی های کلینیکو پاتولوژیک و بقای بیماران مبتلا به بدخیمی های زنان متاستاتیک به مغز
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی


• Identification of poor outcome characteristics and long-term survival indicators
• Increased VEGF-A expression in metastatic brain samples compared to controls
• Multi-modality therapy was associated with improved clinical outcomes.

ObjectiveNo standardized treatment strategies exist for patients with gynecologic malignancies complicated by brain metastases. Identification of poor outcome characteristics, long-term survival indicators, and molecular markers could help individualize and optimize treatment.MethodsThis retrospective cohort study included 100 gynecologic cancer patients with brain metastases treated at our institution between January 1990 and June 2009. Primary outcome was overall survival (OS) from time of diagnosis of brain metastases. We used univariate and multivariate analyses to evaluate associations between OS and clinical factors. We used immunohistochemistry to examine expression of five molecular markers in primary tumors and brain metastases in a subset of patients and matched controls. Statistical tests included the Student's paired t-test (for marker expression) and Kaplan-Meier test (for correlations).ResultsOn univariate analysis, primary ovarian disease, CA-125 < 81 units/mL at brain metastases diagnosis, and isolated versus multi-focal metastases were all associated with longer survival. Isolated brain metastasis remained the only significant predictor on multivariate analysis (HR 2.66; CI 1.19–5.93; p = 0.017). Expression of vascular endothelial growth factor A (VEGF-A) was higher in metastatic brain samples than in primary tumors of controls (p < 0.0001). None of the molecular markers were significantly associated with survival.ConclusionsMulti-modality therapy may lead to improved clinical outcomes, and VEGF therapy should be investigated in treatment of brain metastases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Gynecologic Oncology - Volume 142, Issue 1, July 2016, Pages 76–82
نویسندگان
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