Malignant melanoma arising in a mature teratoma: A case report with review of the recent literature

• We describe a young woman case who initially underwent evaluation for infertility.
• Later she was found to have malignant melanoma arising in a mature dermoid cyst.
• She subsequently underwent USO with staging procedure with benign pathology.
• There was no need for adjuvant therapy and the patient is without disease to date.
• We reviewed the existing literature and this is one of only a few cases documented.

Mature cystic teratomas constitute 10–20% of all ovarian neoplasms. Malignant transformation is very rare occurring in only 0.1–2% of mature teratoma cases. Malignant melanoma is among the least common transformations. Herein, we describe a case of young woman initially undergoing evaluation for infertility who was found to have malignant melanoma arising in a mature dermoid cyst. She subsequently underwent unilateral salpingo-oophorectomy with staging procedure with benign pathology. There was no need for adjuvant therapy and the patient is without disease to date (nearly 10-months in follow-up now). We reviewed the existing literature and this is one of only a few cases documented in the last decade.