کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3966052 1256134 2016 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Spermatotoxic effects of galactose and possible mechanisms of action
ترجمه فارسی عنوان
اثرات اسپرماتوکتومی گالاکتوز و مکانیسم های ممکن عمل
کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی زنان، زایمان و بهداشت زنان
چکیده انگلیسی

While numerous studies have documented the ovotoxic effect of galactose, few available studies on male gonad are of the opinion that it seems to fully escape the toxic effects galactose exerts on the ovary. The present study was therefore designed to further investigate the effects of galactose on male sperm parameters and some reproductive hormones. Thirty male albino rats (200–250 g) were randomly divided in a blinded fashion into 6 groups (n = 5). Group A received normal saline and served as control. Groups B, C, D, E and F received 3 mg/kg, 10 mg/kg, 20 mg/kg, 30 mg/kg, and 40 mg/kg of galactose respectively through oral gavage for 42 days. The results showed that chronic administration of galactose promotes sperm toxicity by reducing epididymal sperm count, motility and percentage of morphologically normal sperm. Moreover, galactose increased luteinizing hormone but slightly decreased testosterone and had no effect on follicle stimulating hormone. Galactose also caused a slight decrease in superoxide dismutase and increase in lactate dehydrogenase activity but no effect on catalase. The present study thus showed that chronic administration of galactose could promote sperm toxicity which could be mediated partly by oxidative stress. Moreover, the response of the hormones is similar to that in premature ovarian insufficiency (POI) in female galactosemic model.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Middle East Fertility Society Journal - Volume 21, Issue 2, June 2016, Pages 82–90
نویسندگان
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