کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
3979710 | 1601108 | 2016 | 6 صفحه PDF | دانلود رایگان |
• CDK12/cycl K complex has a key role in the transcription of specific genes.
• Mutations in CDK12 disable its catalytic function.
• Inhibition of CDK12 offers a new tumor therapeutic strategy.
Phosphorylation of the RNA polymerase II C-terminal domain by cyclin-dependent kinases (CDKs) is important for productive transcription. Deregulated transcription-CDKs have been reported in different human cancers. Until recently CDK9 was the only transcription-CDK with a causative role in cancer, but evidence is cumulating of the importance of CDK12. This review summarizes the role of CDK12 in transcription and RNA processing, in maintaining genomic stability/integrity and in tumorigenesis. CDK12 mutations have been reported in many cancers and have been suggested as a cause of defective DNA repair in ovarian carcinoma. CDK12 may have a role as a new therapeutic target in oncology.
Journal: Cancer Treatment Reviews - Volume 50, November 2016, Pages 83–88