کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
3979710 1601108 2016 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Role and therapeutic potential of CDK12 in human cancers
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی تومور شناسی
پیش نمایش صفحه اول مقاله
Role and therapeutic potential of CDK12 in human cancers
چکیده انگلیسی


• CDK12/cycl K complex has a key role in the transcription of specific genes.
• Mutations in CDK12 disable its catalytic function.
• Inhibition of CDK12 offers a new tumor therapeutic strategy.

Phosphorylation of the RNA polymerase II C-terminal domain by cyclin-dependent kinases (CDKs) is important for productive transcription. Deregulated transcription-CDKs have been reported in different human cancers. Until recently CDK9 was the only transcription-CDK with a causative role in cancer, but evidence is cumulating of the importance of CDK12. This review summarizes the role of CDK12 in transcription and RNA processing, in maintaining genomic stability/integrity and in tumorigenesis. CDK12 mutations have been reported in many cancers and have been suggested as a cause of defective DNA repair in ovarian carcinoma. CDK12 may have a role as a new therapeutic target in oncology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Treatment Reviews - Volume 50, November 2016, Pages 83–88
نویسندگان
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