کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4011095 1602574 2016 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Increased production of omega-3 fatty acids protects retinal ganglion cells after optic nerve injury in mice
ترجمه فارسی عنوان
افزایش تولید اسیدهای چرب امگا 3 از سلول های گانگلیونی شبکیه پس از آسیب عصب بینایی در موش محافظت می کند
کلمات کلیدی
آسیب عصب بینایی؛ سلول های گانگلیونی شبکیه؛ بقا؛ اسیدهای چرب امگا 3 ؛ مسیر ERK1/2 ؛ cAMP
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی و میکروب شناسی (عمومی)
چکیده انگلیسی


• Omega-3 enhanced retinal ganglion cell survival, but not axonal regeneration.
• cAMP elevation does not potentiate the actions of omega-3 fatty acids.
• The neuroprotection is achieved partially through ERK1/2 pathway.
• Our study provides important information for understanding of neural repair.

Injury to the central nervous system causes progressive degeneration of injured axons, leading to loss of the neuronal bodies. Neuronal survival after injury is a prerequisite for successful regeneration of injured axons. In this study, we investigated the effects of increased production of omega-3 fatty acids and elevation of cAMP on retinal ganglion cell (RGC) survival and axonal regeneration after optic nerve (ON) crush injury in adult mice. We found that increased production of omega-3 fatty acids in mice enhanced RGC survival, but not axonal regeneration, over a period of 3 weeks after ON injury. cAMP elevation promoted RGC survival in wild type mice, but no significant difference in cell survival was seen in mice over-producing omega-3 fatty acids and receiving intravitreal injections of CPT-cAMP, suggesting that cAMP elevation protects RGCs after injury but does not potentiate the actions of the omega-3 fatty acids. The observed omega-3 fatty acid-mediated neuroprotection is likely achieved partially through ERK1/2 signaling as inhibition of this pathway by PD98059 hindered, but did not completely block, RGC protection. Our study thus enhances our current understanding of neural repair after CNS injury, including the visual system.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Experimental Eye Research - Volume 148, July 2016, Pages 90–96
نویسندگان
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