Sodium orthovanadate effect on outflow facility and intraocular pressure in live monkeys

► Sodium orthovanadate increases outflow facility and lowers intraocular pressure in live monkeys. ► Vanadate reversibly disrupts the actin cytoskeleton and cell adhesion architecture of cultured trabecular meshwork cells. ► Altered actin architecture in the trabecular meshwork may play a role in the effect of vanadate on outflow facility.