کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4012741 | 1261207 | 2006 | 9 صفحه PDF | دانلود رایگان |
Following ocular HSV-1 infection, neovascularisation of the avascular cornea is a critical event in the pathogenesis of herpetic stromal keratitis. This present study evaluates the role of proinflammatory cytokines such as IL-6 in corneal angiogenesis following virus infection. Both in vivo and in vitro data indicate that IL-6 produced from virus-infected cells can stimulate noninfected resident corneal cells and other inflammatory cells in a paracrine manner to secrete VEGF, a potent angiogenic factor. Antibody neutralisation of IL-6 resulted in a significant decrease in the number of VEGF producing cells in the cornea. Thus, our results further demonstrate the close relationship between proinflammatory cytokines and VEGF-induced corneal neovascularisation.
Journal: Experimental Eye Research - Volume 82, Issue 1, January 2006, Pages 46–54