کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4093773 | 1268424 | 2012 | 5 صفحه PDF | دانلود رایگان |
In knee arthroplasty patients with complications not explained by classical mechanisms, like infection or malalignment/malposition, the role of hypersensitivity to implant materials may be questioned. In 10 such patients with and 5 without metal sensitization, a combined evaluation of periimplant histology and cytokine expression, and microbiological analysis was done. In the 10 metal allergics, outcome after revision with alternative “hypoallergenic” materials (9×titanium-based, 1×oxinium-based) was evaluated. In the metal-allergic patients, scattered, partly dense T-lymphocytes were seen in periimplant tissue and there were no signs of infection. Predominant IFN-γ expression and the improvement in the postoperative WOMAC scores (mean preoperative score, 40.4; postoperative score, 55.58) supported hypersensitivity as the symptoms elicitor.
Journal: Seminars in Arthroplasty - Volume 23, Issue 4, December 2012, Pages 268–272