کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4114834 1606077 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Effect of paranasal sinusitis on the development of otitis media with effusion: Influence of Eustachian tube function and adenoid immunity
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Effect of paranasal sinusitis on the development of otitis media with effusion: Influence of Eustachian tube function and adenoid immunity
چکیده انگلیسی

SummaryObjectivesConcordance between sinusitis and otitis media with effusion (OME) has been reported in 5–60% of patients. Since nasal diseases induce edema and lymphoid tissue hyperplasia in the nasopharyngeal mucosa, especially the adenoids, chronic infection of the adenoids has been reported to induce otitis media. In addition, deterioration in the mucosal barrier of the adenoids makes the latter vulnerable to bacterial infections, resulting in OME or sinusitis. We therefore evaluated adenoid local immunity and Eustachian tube function by sinusitis and the concordance between sinusitis and OME.Materials and methodsWe examined PNS series and tympanometry of 520 patients who had undergone adenotonsillectomies. In addition, local adenoidal immunity was evaluated in 10 children with OME and sinusitis, 11 with only sinusitis, 10 with only OME and 12 with no history of OME or sinusitis. Adenoid size, squamous metaplasia, IgA, BCL-6, and mucosal barrier were also determined.ResultsOf 520 patients, 80 (15.4%) had both OME and sinusitis. The incidence of Eustachian tube dysfunction differed significantly between patients with and without sinusitis (p = 0.03). The incidence of squamous metaplasia differed significantly between patients with sinusitis plus OME and patients with sinusitis alone (p = 0.01), and between patients with OME alone and those without both conditions (p = 0.005). Patients with both sinusitis and OME differed significantly in IgA secretion (p = 0.01) and Bcl-6 expression (p = 0.02) from those with sinusitis alone, as did patients with OME alone and those without both conditions (p = 0.02 and p = 0.03, respectively).ConclusionsSinusitis plus OME were present in 15.4% of patients. Eustachian tube dysfunction was present in 37.9% of sinusitis patients and in 28.4% of those without sinusitis. IgA, BCL-6 and squamous metaplasia were important in local adenoidal immunity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pediatric Otorhinolaryngology - Volume 72, Issue 11, November 2008, Pages 1609–1618
نویسندگان
, , , , , ,