Association between Foot Growth and Musculoskeletal Loading in Children with Prader-Willi Syndrome before and during Growth Hormone Treatment

In PWS, FL is positively associated with musculoskeletal loading. Small feet in children with PWS before and during long-term GHT may be more than just another dysmorphic feature, but may possibly reflect decreased musculoskeletal loading influencing foot growth and genetic and endocrine factors.