کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4208565 1280451 2013 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Secretory IgA as a diagnostic tool for Pseudomonas aeruginosa respiratory colonization
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی پزشکی ریوی و تنفسی
پیش نمایش صفحه اول مقاله
Secretory IgA as a diagnostic tool for Pseudomonas aeruginosa respiratory colonization
چکیده انگلیسی

BackgroundPseudomonas aeruginosa sinusitis may be the focus for intermittent lung colonization in patients with cystic fibrosis (CF). The sinusitis may induce elevated IgA levels in nasal secretion and saliva against P. aeruginosa.Methods120 CF patients chronically infected, intermittently colonized or without P. aeruginosa in the lungs participated in this cross-sectional study. IgA and IgG against P. aeruginosa sonicate and alginate were measured in nasal secretions, saliva, and in serum by ELISA.ResultsThe intermittently colonized patients had significantly higher IgA levels in nasal secretions and saliva than those without P. aeruginosa in the lungs, indicating that P. aeruginosa sinusitis may precede intermittent colonization and chronic infection of the lungs.ConclusionsSpecific IgA against P. aeruginosa in nasal secretions and saliva can contribute to differentiation between patients chronically infected, intermittently colonized, and without P. aeruginosa in the lungs. The diagnostic value of the IgA ELISA awaits a prospective study.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Cystic Fibrosis - Volume 12, Issue 1, January 2013, Pages 81–87
نویسندگان
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