Intraprocedural Yttrium-90 Positron Emission Tomography/CT for Treatment Optimization of Yttrium-90 Radioembolization

Radioembolization with yttrium-90 (90Y) microspheres relies on delivery of appropriate treatment activity to ensure patient safety and optimize treatment efficacy. We report a case in which 90Y positron emission tomography (PET)/computed tomography (CT) was performed to optimize treatment planning during a same-day, three-part treatment session. This treatment consisted of (i) an initial 90Y infusion with a dosage determined using an empiric treatment planning model, (ii) quantitative 90Y PET/CT imaging, and (iii) a secondary infusion with treatment planning based on quantitative imaging data with the goal of delivering a specific total tumor absorbed dose.