Variability of Apoptosis and Response in N1-S1 Rodent Hepatomas to Benzamide Riboside and Correlation to Early Changes in Water Apparent Diffusion Coefficient and Sodium MR Imaging

Apoptosis was marginal and varied from 2% to 10%. Water ADC, SQ, and TQF MR imaging distinguished tumor from nontumor. Changes in water ADC and sodium MR imaging correlated to apoptosis and volume in select cases, but additional animals are needed to validate this trend against tumor growth.