کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4313344 1289994 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Human memory manipulated: Dissociating factors contributing to MTL activity, an fMRI study
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Human memory manipulated: Dissociating factors contributing to MTL activity, an fMRI study
چکیده انگلیسی

Memory processes are mainly studied with subjective rating procedures. We used a morphing procedure to objectively manipulate the similarity of target stimuli. While undergoing functional magnetic resonance imaging, nineteen subjects performed a encoding and recognition task on face and scene stimuli, varying the degree of manipulation of previously studied targets at 0%, 20%, 40% or 60%. Analyses were performed with parametric modulations for objective stimulus status (morphing level), subjective memory (confidence rating), and reaction times (RTs). Results showed that medial temporal lobe (MTL) activity can be best explained by a combination of subjective and objective factors. Memory success is associated with activity modulation in the hippocampus both for faces and for scenes. Memory failures correlated with lower hippocampal activity for scenes, but not for faces. Activity changed during retrieval on similar areas activated during encoding. There was a considerable impact of RTs on memory-related areas. Objective perceptual identity correlated with activity in the left MTL, while subjective memory experience correlated with activity in the right MTL for both types of material. Overall, the results indicate that MTL activity is heterogeneous, showing both linear and non-linear activity, depending on the factor analyzed.


► Morphed stimuli were used to obtain gradual memory weakening.
► Faces and scenes elicited hippocampal activity during encoding and retrieval.
► MTL activity correlated with a combination of subjective and perceptual factors.
► Reaction times were highly correlated with activity in MTL areas.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Behavioural Brain Research - Volume 229, Issue 1, 1 April 2012, Pages 57–67
نویسندگان
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