Spatial frequency threshold and contrast sensitivity of an optomotor behavior are impaired in the Ins2Akita mouse model of diabetes

Diabetic retinopathy can lead to progressive loss of vision and is a leading cause of blindness. The Ins2Akita mouse model of diabetes develops significant retinal and systemic pathology, but how these affect visual behavior is unknown. Here, we show that Ins2Akita mice have progressive, quantifiable vision deficits in an optomotor behavior. This mouse line is a promising model in which to understand the contribution of retinal neuronal injury during the chronic hyperglycemia and hypoinsulinemia of diabetes to deficits in vision.

► We find Ins2Akita diabetic mice have visual performance deficits.
► The optokinetic tracking response to drifting gratings was measured.
► Spatial frequency threshold and contrast sensitivity declined during diabetes.
► Spatial frequency threshold deficits were correlated to blood glucose levels.