کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4318659 1613235 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Metformin prevents cerebellar granule neurons against glutamate-induced neurotoxicity
ترجمه فارسی عنوان
متفورمین مانع از نورون‌های گرانشی مخچه در برابر سمیت نورونی ناشی از گلوتامات می شود
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب سلولی و مولکولی
چکیده انگلیسی


• Metformin pretreatment protects CGNs against glutamate neuronal toxicity.
• Metformin reduces glutamate-induced Caspase 3 activation.
• Glutamate-induced JNK and p38 phosphorylation are inhibited by metformin.

Metformin, a wildly used drug for type 2 diabetes, has recently been proven to protect a variety of cells from stress including stroke. Glutamate is an excitatory neurotransmitter that contributes to excitatory neuronal damage involved in stroke and neurodegenerative disorders. In this study, we demonstrated that pretreatment of rat cerebellar granule neurons (CGN) with metformin greatly enhanced cell viability against glutamate-induced neurotoxicity. Metformin significantly attenuated neuronal apoptosis in glutamate-treated CGN by reducing cytochrome c releasing, caspase-3 activation and phosphorylation of MAP kinases. Our results suggested that metformin was able to directly inhibit glutamate induced excitotoxicity in neurons and might be beneficial to patients suffered from stroke and neurodegenerative disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 121, March 2016, Pages 241–245
نویسندگان
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