کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4319891 | 1290836 | 2008 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder
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کلمات کلیدی
CCH4-DAMP4-diphenylacetoxy-N-methylpiperidine methiodideBladder contractilityNANCnon-adrenergic, non-cholinergicAdenosine Triphosphate - آدنوزین تری فسفاتATP - آدنوزین تری فسفات یا ATPReceptor interaction - تعامل گیرندهBladder smooth muscle - عضله صاف مثانهNon-adrenergic - غیر آدرنرژیکCarbachol - کارباکولMuscarinic acetylcholine receptors - گیرنده های استیل کولین Muscarinicnicotinic acetylcholine receptors - گیرنده های استیل کولین نیکوتین
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب سلولی و مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder](/preview/png/4319891.png)
چکیده انگلیسی
In the present study, the plasticity of the non-adrenergic non-cholinergic (NANC) response was investigated. Isolated rat bladder strips were electrically stimulated and the evoked contractions were isometrically recorded. The NANC part of the contractions were unmasked by applying 500 nM 4-DAMP, a potent muscarinic antagonist. Treatment of the bladder strips with 10 μM carbachol (a cholinergic agonist) increased the muscle tone but did not alter the neurally evoked contractions. However, carbachol decreased: (1) the NANC response from 74.6% to 33.3% of control and (2) the purinergic contractile response to α,β-methylene ATP (α,β-mATP) (10 μM) from 97.0% to 43.4% (p < 0.05). Treatment with the cholinesterase inhibitor eserine (10 μM) also significantly decreased the NANC response to 21.1% (p < 0.0001). The purinergic receptor antagonist suramin (100 μM) did not affect the neurally evoked contractions, however; subsequent addition of 4-DAMP decreased the contractions to 31%. Activation of the smooth muscle cholinergic receptors (with carbachol or eserine) and purinergic receptors (with α,β-mATP) decreased the NANC contractions and the direct contractile response to α,β-mATP. When the electrically evoked contractions were facilitated by the L-type Ca2+ channel activator, Bay-K 8644 the subsequent application of 4-DAMP did not unmask inhibited NANC contractions. We conclude that activation of muscarinic receptors by cholinergic agonist, carbachol or by endogenous acetylcholine (ACh) induce a cascade of events that leads to diminished purinergic response and consequently an inhibition of the bladder NANC response.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Bulletin - Volume 77, Issue 6, 16 December 2008, Pages 420-426
Journal: Brain Research Bulletin - Volume 77, Issue 6, 16 December 2008, Pages 420-426
نویسندگان
H. Henry Lai, Christopher P. Smith, Alvaro Munoz, Timothy B. Boone, Gyula P. Szigeti, George T. Somogyi,