کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4323556 1613800 2016 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The therapeutic effect of curcumin in male albino rats and its putative mechanisms on cerebral microvascular flow
ترجمه فارسی عنوان
اثر درمانی کورکومین در موش های صحرایی نر بالغ و مکانیسم های احتمالی آن بر جریان مایکروویو مغزی
کلمات کلیدی
کرکومین؛ موش؛ فشار خون بالا؛ فشار خون؛ میکروسیرکولاسیون
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• Curcumin increased blood velocity.
• Curcumin LDF flow.
• Curcumin altered the circulating endothelial cells.
• Curcumin altered open capillaries number.
• Useful in microcirculatory and hypertension regulation.

The present study aimed to investigate the therapeutic effect of curcumin on hypertension and its putative mechanisms in the cerebral microcirculation. The surgical preparation was made to generate a cranial window for observation of the capillary network in the cerebral cortex region. Digital image processing, intravital videomicroscopy, and laser Doppler flow meter were used in this investigation. The number of open capillaries, arterial blood pressure, red cell velocity, microvascular diameter, circulating endothelial cells, relative blood flow and frequency were determined. Control rats showed severe dysfunction in the microcirculation with increased blood pressure. In curcumin treated mice, the blood pressure significantly reduced compared to their respective controls. Curcumin significantly increased blood velocity and LDF flow in hypertensive and normotensive rats. Curcumin significantly altered the circulating endothelial cells and open capillaries number in the male albino rats. Our results suggested that the curcumin exerts its therapeutic effect in male albino rats by regulating vasomotion function, increasing blood perfusion, releasing the peripheral resistance and opening efficiently capillaries. Taking all these data together, it is concluded that the curcumin might be useful in the regulation of the cerebral microcirculatory function and hypertension.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1642, 1 July 2016, Pages 131–135
نویسندگان
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