کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4324027 1613845 2015 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Administration of human platelet-rich plasma reduces infarction volume and improves motor function in adult rats with focal ischemic stroke
ترجمه فارسی عنوان
تجویز پلاسمای غنی از پلاکت خون انسان باعث کاهش حجم انفارکتوس و بهبود عملکرد موتور در موش های بالغ با سکته مغزی ایسکمیک کانونی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
چکیده انگلیسی


• The study examined platelet-rich plasma (PRP)’s utility in experimental ischemic stroke.
• Growth factor levels in PRP lysate samples were determined by ELISA in vitro.
• Intra-arterial PRP lysate reduced infarct volume and neurological deficit compared to systemic PRP lysate or control treatment.
• Present data suggest that local PRP lysate infusion into the ischemic area offers a novel approach for stroke.

Platelet-rich plasma (PRP) is a milieu of bioactive factors, including platelet derived growth factor, transforming growth factor beta, among many others. Despite accumulating evidence on PRP’s safety and efficacy for treating musculoskeletal injuries, limited studies have been performed using PRP in brain disorders. This study aimed to explore the potential benefits of administration of human PRP lysate after ischemic stroke in rats. An ischemic stroke model was generated by occlusion of the right middle cerebral artery, then 90 min later, stroke rats were randomly assigned to receive local infusion to the ischemic area of human PRP lysate, human albumin solution (HSA), saline or no treatment at all. An additional group of stroke rats received systemic infusion of human PRP lysate to further assess the therapeutic effects of this treatment. Results showed that while local infusion of HSA or saline, and systemic administration of human PRP lysate, compared to no treatment significantly reduced infarct volume (37.4%, 40.1%, and 39.9% vs 49.7%) and neurological deficit score (2.2, 2.6, and 2.8 vs 3.7), the greatest neuroprotection (31.0% infarct volume and 1.6 neurological deficit score) was found in stroke animals that received local intra-arterial infusion of human PRP lysate (p’s<0.05). In conclusion, administration of human PRP attenuates brain injury after focal ischemia. Our results suggest PRP should be investigated further as a potential point-of-care biomaterial following stroke.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1594, 12 January 2015, Pages 267–273
نویسندگان
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