کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4325906 1614044 2011 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Rifampicin inhibits microglial inflammation and improves neuron survival against inflammation
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Rifampicin inhibits microglial inflammation and improves neuron survival against inflammation
چکیده انگلیسی

Microglial activation plays an important role in the pathophysiology of neurodegenerative diseases, and suppression of microglial activation prevents the progression of neurodegeneration. Rifampicin, a bacteriocidal antibiotic, induces immunosuppression. We hypothesized that rifampicin might be neuroprotective by inhibiting the production of pro-inflammatory mediators, thereby suppressing microglial activation. In the present study, we examined the effects of rifampicin on the production of lipopolysaccharide (LPS)-induced pro-inflammatory mediators and their signaling pathways in BV2 microglia. We also assessed the neuroprotective effects of rifampicin using a co-culture of microglia and neurons. Our results showed that rifampicin inhibited the LPS-stimulated expression of inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-α, and interleukin-1β, as well as the production of nitric oxide and prostaglandin E2. Moreover, rifampicin suppressed LPS-induced nuclear factor-kappa B activation by blocking the degradation of the inhibitor of the nuclear transcription factor NF-kappa B. Rifampicin inhibited the phosphorylation of mitogen activated protein kinases, although protein kinase B was not inhibited. Preincubation of microglia with rifampicin reduced neurotoxicity and improved neuron survival in a microglia–neuronal co-culture system. Taken together, these findings suggest that rifampicin, with its anti-inflammatory properties, might be a novel treatment for neurodegenerative diseases.

Research highlights
► Rifampicin is an effective antiinflammatory agent.
► Rifampicin can inhibit the production of proinflammory factors through downregulation of NF-κB and MAPKs pathway.
► Rifampicin may have a possible therapeutic application in the treatment of neuroinflammatory disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1395, 13 June 2011, Pages 12–20
نویسندگان
, , , , , , ,