کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4327687 1614139 2009 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Dystrophic dendrites in prefrontal cortical pyramidal cells of dopamine D1 and D2 but not D4 receptor knockout mice
چکیده انگلیسی

Recent data indicate that cortical dopamine denervation results in dystrophic changes in the dendrites of pyramidal cells, including decreases in dendritic spine density and length. However, it is not known if the loss of signaling through specific dopamine receptors subserves these dendritic changes. We examined the dendritic structure of layer V pyramidal cells in the prefrontal cortex of D1, D2, and D4 dopamine receptor null mutant mice and their wild-type littermates. Decreased basal dendritic length and spine density were observed in the D1 knockout mice. Similarly, a decrease in basal dendritic spine density was uncovered in the D2 knockout mice relative to wild-type littermates. No changes in any dendritic parameter were observed in the D4 knockout mice. These observations suggest that the dystrophic changes observed in prefrontal cortical pyramidal cell dendrites are due to loss of signaling through D1 and possibly D2 receptors. The current data also suggest that caution should be exercised in the interpretation of behavioral, physiological, and biochemical studies of the prefrontal cortex in dopamine receptor knockout mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1300, 10 November 2009, Pages 58–64
نویسندگان
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