کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4328870 | 1614194 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bed nucleus of the stria terminalis α1-adrenoceptor modulates baroreflex cardiac component in unanesthetized rats
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کلمات کلیدی
NTSNoradrenergic neurotransmissionPAPHmbBSTACFbaroreflex - رفلکس بارورسپتورParasympathetic nervous system - سیستم عصبی پاراسمپاتیکCardiovascular system - سیستم قلبی عروقیHeart rate - ضربان قلبpulsatile arterial pressure - فشار خون شریانmean arterial pressure - فشار متوسط شریانیBlood pressure - فشارخونartificial cerebrospinal fluid - مایع مغزی نخاعی مصنوعیmap - نقشهbed nucleus of the stria terminalis - هسته تخت ترمینال های استریNucleus tractus solitarii - هسته دستگاه انفرادی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The bed nucleus of stria terminalis (BST) has a tonic modulating role on the baroreflex parasympathetic component. In the present study, we verified that local BST-adrenoceptors modulate baroreflex-evoked bradycardiac responses in unanesthetized rats. Bilateral microinjection of the selective α1-adrenoceptor antagonist WB4101 (15 nmol/100 nL) into the BST increased the gain of reflex bradycardia in response to mean arterial pressure increases caused by intravenous (i.v.) infusion of phenylephrine, suggesting that BST α1-adrenoceptors modulate baroreflex bradycardiac response. Bilateral microinjection of either the selective α2-adrenoceptor antagonist RX821002 (15 nmol/100 nL) or the non-selective β-adrenoceptor antagonist propranolol (15 nmol/100 nL) into the BST had not affected baroreflex bradycardia. Animals were pretreated intravenously with the cholinergic muscarinic receptor antagonist homatropine methyl bromide (HMB, 1.5 mg/Kg) to test the hypothesis that activation of α1-adrenoceptors in the BST would modulate the baroreflex parasympathetic component. Baroreflex bradycardiac responses evoked before and after BST treatment with WB4101 were no longer different when rats were pretreated with HMB. These results suggest that parasympathetic activation accounts for the effects saw after BST pharmacological manipulation and ruling out the possibility of a sympathetic withdraw. In conclusion, our data point out that local α1-adrenoceptors mediate the BST tonic influence on the baroreflex bradycardiac response modulating parasympathetic cardiac activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research - Volume 1245, 15 December 2008, Pages 108-115
Journal: Brain Research - Volume 1245, 15 December 2008, Pages 108-115
نویسندگان
Carlos C. Crestani, Fernando H.F. Alves, Leonardo B.M. Resstel, Fernando M.A. Correa,