کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4331862 | 1614312 | 2007 | 9 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease Gene expression profiles of metabolic enzyme transcripts in Alzheimer's disease](/preview/png/4331862.png)
The successfully functioning brain is a heavy user of metabolic energy. Alzheimer's disease, in which cognitive faculties decline, may be due, at least in part, to metabolic insufficiency. Using microarray analysis and quantitative RT-PCR, the expression of mRNA transcripts involved in glucose metabolism was investigated in Alzheimer's diseased post-mortem human hippocampal samples. Of the 51 members of the glycolytic, tricarboxylic acid cycle, oxidative phosphorylation, and associated pathways investigated by qPCR, 15 were confirmed to be statistically significantly (p < 0.05) down-regulated in Alzheimer's disease. This finding suggests that reductions in the levels of transcripts encoded by genes that participate in energy metabolism may be involved in Alzheimer's disease.
Journal: Brain Research - Volume 1127, 5 January 2007, Pages 127–135