کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4333902 | 1294758 | 2006 | 13 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Regulatory mechanisms of cortical laminar development
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
FACSLGEBLBPSVZWntTlxPax6NeuroblastsGLASTLoxPMGEGADFGFSEYOSVZGFPTN-CCREDiI - DIIγ-amino butyric acid - γ-آمینو اسید بوتیریکlateral ganglionic eminence - برجسته گانگلیونی جانبیBrdU - بروموداکسی اوریدینbromodeoxyuridine - برومودسوویریدینCell differentiation and migration - تمایز سلولی و مهاجرتTenascin - تنگاسینDevelopment and regeneration - توسعه و بازسازیfluorescent-activated cell sorting - دسته بندی سلول فعال فعال فلورسنتcortical plate - صفحه قشرTranscription factor - عامل رونویسیfibroblast growth factor - فاکتور رشد فیبروبلاستCortex - قشرventricular zone - منطقه بطنیmarginal zone - منطقه حاشیه ایsubventricular zone - منطقه فرعیintermediate zone - منطقه متوسطmedial ganglionic eminence - میانه گانگلیونیNeurogenesis - نوروژنزgreen fluorescent protein - پروتئین فلورسنت سبزbrain lipid-binding protein - پروتئین چسبندگی به مغزCorticogenesis - کورتیکوژنزGABA - گابا
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The developing forebrain exhibits a high degree of spatiotemporal regulation of proliferation and cell cycle exit in progenitor cells of its proliferative zones. This results in the balanced deployment of progenitors between asymmetric division, yielding postmitotic neurons and cycling progenitors, and terminal symmetric division, resulting in differentiated daughter cells. Radial glia have been demonstrated to be the principal neuronal progenitor of the cortical primordium. Lineage tracing studies employing real-time imaging in vivo have enhanced understanding of neuronal production and migration. Cortical projection neurons have been shown to arise from the radial migration of precursors generated in the dorsal telencephalon, whereas most interneurons derive from the germinal zone of the ventral telencephalon and migrate tangentially into the primordial cortex. Cells from both populations undergo diverse and complex sequences of migratory activity. Neuronal phenotypic potential is informed in progenitors prior to their last cell division. Laminar and regional fate potential of progenitors becomes progressively restricted with successive cell cycles. This process of neuronal fate specification is regulated by the interaction of programs of transcriptional regulation with extrinsic patterning signals according to time and region of the proliferative zone in which the final mitotic cycle occurs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain Research Reviews - Volume 51, Issue 1, June 2006, Pages 72-84
Journal: Brain Research Reviews - Volume 51, Issue 1, June 2006, Pages 72-84
نویسندگان
Manuel F. Casanova, Juan II,