کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4336856 | 1614659 | 2006 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Time-frequency analysis of spike-wave discharges using a modified wavelet transform
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The continuous Morlet wavelet transform was used for the analysis of the time-frequency pattern of spike-wave discharges (SWD) as can be recorded in a genetic animal model of absence epilepsy (rats of the WAG/Rij strain). We developed a new wavelet transform that allows to obtain the time-frequency dynamics of the dominating rhythm during the discharges. SWD were analyzed pre- and post-administration of certain drugs. SWD recorded predrug demonstrate quite uniform time-frequency dynamics of the dominant rhythm. The beginning of the discharge has a short period with the highest frequency value (up to 15Â Hz). Then the frequency decreases to 7-9Â Hz and frequency modulation occurs during the discharge in this range with a period of 0.5-0.7Â s. Specific changes of SWD time-frequency dynamics were found after the administration of psychoactive drugs, addressing different brain mediator and modulator systems. Short multiple SWDs appeared under low (0.5Â mg/kg) doses of haloperidol, they are characterized by a fast frequency decrease to 5-6Â Hz at the end of every discharge. The frequency of the dominant frequency of SWD was not stable in long lasting SWD after 1.0Â mg/kg or more haloperidol: then two periodicities were found. Long lasting SWD seen after the administration of vigabatrin showed a stable frequency of the discharge. The EEG after Ketamin showed a distinct 5Â s quasiperiodicity. No clear changes of time-frequency dynamics of SWD were found after perilamine. It can be concluded that the use of the modified Morlet wavelet transform allows to describe significant parameters of the dynamics in the time-frequency domain of the dominant rhythm of SWD that were not previously detected.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Neuroscience Methods - Volume 154, Issues 1â2, 30 June 2006, Pages 80-88
Journal: Journal of Neuroscience Methods - Volume 154, Issues 1â2, 30 June 2006, Pages 80-88
نویسندگان
Daria Bosnyakova, Alexandra Gabova, Galina Kuznetsova, Yuri Obukhov, Inna Midzyanovskaya, Dmitrij Salonin, Clementina van Rijn, Anton Coenen, Leene Tuomisto, Gilles van Luijtelaar,