کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4338665 | 1614877 | 2011 | 13 صفحه PDF | دانلود رایگان |
In the present study, orexinergic cell bodies within the brains of rhythmic and arrhythmic circadian chronotypes from three species of African mole rat (Highveld mole rat—Cryptomys hottentotus pretoriae, Ansell's mole rat—Fukomys anselli and the Damaraland mole rat—Fukomys damarensis) were identified using immunohistochemistry for orexin-A. Immunopositive orexinergic (Orx+) cell bodies were stereologically assessed and absolute numbers of orexinergic cell bodies were determined for the distinct circadian chronotypes of each species of mole rat examined. The aim of the study was to investigate whether the absolute numbers of identified orexinergic neurons differs between distinct circadian chronotypes with the hypothesis of elevated hypothalamic orexinergic neurons in the arrhythmic chronotypes compared with the rhythmic chronotypes. We found statistically significant differences between the circadian chronotypes ofF. anselli, where the arrhythmic group had higher mean numbers of hypothalamic orexin neurons compared with the rhythmic group. These differences were observed when the raw data was compared and when the raw data was corrected for body mass (Mb) and brain mass (Mbr). For the two other species investigated, no significant differences were noted between the chronotypes, although a statistically significant difference was noted between all rhythmic and arrhythmic individuals of the current study when the counts of orexin neurons were corrected for Mb—the arrhythmic individuals had larger numbers of orexin cells.
▶(1) Orexin neurons of three species of molerat with unusual circadian rhythms are quantified. ▶(2) These mole rats show a rodent like orexin system, despite a reduced visual system. ▶(3) There are more orexin neurons in arrhythmic animals when corrected for body mass.
Journal: Neuroscience - Volume 199, 29 December 2011, Pages 153–165