کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4338810 1614882 2011 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intranasal administration of insulin-like growth factor-1 protects against lipopolysaccharide-induced injury in the developing rat brain
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب (عمومی)
پیش نمایش صفحه اول مقاله
Intranasal administration of insulin-like growth factor-1 protects against lipopolysaccharide-induced injury in the developing rat brain
چکیده انگلیسی
▶Neonatal LPS exposure results in oligodendrocyte and white matter injury. ▶rhIGF-1 administered through intranasal infusion can penetrate into the neonatal rat brain. ▶Intranasal infusion of IGF-1 up to 2 h after LPS exposure attenuates LPS-induced brain injury. ▶Intranasal infusion of IGF-1 improved neurobehavioral deficits induced by LPS in juvenile rats. ▶rhIGF-1 attenuates LPS-induced apoptotic cell death, but not LPS-induced acute immune responses.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience - Volume 194, 27 October 2011, Pages 195-207
نویسندگان
, , , , ,