Maternal exposure to the CB1 cannabinoid agonist WIN 55212-2 produces robust changes in motor function and intrinsic electrophysiological properties of cerebellar Purkinje neurons in rat offspring

▶ Although acute cannabinoid treatment effects have been extensively studied, little is known concerning the effects of prolonged exposure to CB1 agonists on neuronal intrinsic properties. ▶This manuscript examines the effects of prenatal cannabinoid exposure on motor function and intrinsic cellular properties of Purkinje cells at postnatal day 50. ▶Our findings show that WIN treatment of pregnant rats produced significant changes in several behavioral measures related to exploratory behavior and also affected the intrinsic firing rate and other aspects of Purkinje cell electrophysiology.