کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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4339120 | 1614897 | 2011 | 8 صفحه PDF | دانلود رایگان |
Quinpirole-sensitized rats were tested on a discrete-trials 40-s peak-interval procedure using lever pressing as the instrumental response. Although there was no evidence of rhythmical activity in lever pressing, periodic output was observed in a secondary response (food-cup entries) during the inter-trial interval following the delivery of reinforcement on fixed-interval trials, but not during unreinforced probe trials. This repetitive pattern of behavior with a 40-s period points to the primacy of reinforcement as a time marker and an increased tendency to synchronize to noisy and sparse periodic input as a result of reduced inhibitory control in cortico-striatal circuits following chronic quinpirole administration. Parallels between quinpirole-induced rhythmical behavior and the repetitive motor habits frequently observed in obsessive-compulsive disorder are discussed.
Research highlights▶Rats are studied using a 40-s peak-interval timing procedure. ▶We examine changes in timing as a function of quinpirole administration. ▶Quinpirole-induced rhythmical behavior similar to the repetitive motor habits frequently observed in obsessive-compulsive disorder. ▶Observations are discussed in terms of excitation and inhibition of cortical-striatal circuits.
Journal: Neuroscience - Volume 179, 14 April 2011, Pages 143–150