Antidepressant-like effect of 1-(7-methoxy-2-methyl-1,2,3,4-tetrahydro-isoquinolin-4-YL)-cyclohexanol, a putative trace amine receptor ligand involves l-arginine-nitric oxide-cyclic guanosine monophosphate pathway

► Nitric oxide is involved in major depression and the action of many antidepressants. ► The molecule described in this paper is a novel trace amine receptor modulator. ► Nitric oxide is involved in the antidepressant effect of this new molecule. ► Such molecules are future drug of choice for major depression.