Direct intra-accumbal infusion of a beta-adrenergic receptor antagonist abolishes WIN 55,212-2-induced aversion

► The synthetic cannabinoid agonist WIN 55,212-2 induces conditioned place aversion. ► Betaxolol in the nucleus accumbens blocks WIN 55,212-2-induced aversion. ► Potential use of beta blockers to block cannabinoid side effects.