کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4351426 | 1615306 | 2013 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Effects of medullary lesions on conditional pacemaker activity of neonatal rat hypoglossal motoneurons in vitro
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کلمات کلیدی
PBCNIRNSTSPVCpGNMDAN-methyl-d-aspartateDMXMedulla oblongataVRGSp5 - sp5Spinal trigeminal tract - تریژمنیال ستون فقراتSolitary tract - دستگاه تناسلیDevelopment - رشدRhythm - ریتم، ضربآهنگTongue - زبان(کالبدشناسی)inferior olive - زیتون ناقصSol - سلWhole-cell recording - ضبط کامل سلولhypoglossal motoneuron - موترونورون hypoglossalSucking - مکیدنnucleus of the solitary tract - هسته دستگاه انفرادیspinal trigeminal nucleus - هسته سه گانه نخاعیNucleus ambiguous - هسته مبهم استdorsal motor nucleus of the vagus - هسته موتور پشتی وحشیCentral Pattern Generator - ژنراتور الگوی مرکزیcentral canal - کانال مرکزیVentral respiratory group - گروه تنفسی انسدادی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
N-methyl-d-aspartate (NMDA) has been demonstrated to induce rhythmic activity in various neurons, including hypoglossal motoneurons (XIIms) and converts them to conditional pacemakers. Using whole-cell patch clamp recording in a slice preparation from neonatal rats, we confirmed that some XIIms act as conditional pacemakers, with TTX-insensitivity and a burst period that is voltage-dependent during NMDA application. Other XIIms in this study only fired tonically with NMDA application. Effects of medullary structures on conditional pacemaker XIIms were assessed using lesioned preparations. As a result, NMDA-induced rhythm (NIR) in the XIIm was observed with ventral lesions (excluding inspiratory neurons) and with dorsal lesions (excluding the swallowing center located in the nucleus of the solitary tract). The NIR was also observed with lateral lesions, but with a significantly decreased burst period. These data suggest that NMDA receptor activation selects a subset of XIIms and changes them to pacemakers whose properties can be altered by their excitability. The data also demonstrate that structures fundamental to the NIR are located within the area near the XII nucleus, indicating that the NIR is distinct from inspiratory and swallowing activities. The lateral medulla is considered to be a source of modulation of the excitability of XIIms.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 76, Issues 1â2, MayâJune 2013, Pages 42-51
Journal: Neuroscience Research - Volume 76, Issues 1â2, MayâJune 2013, Pages 42-51
نویسندگان
Hidenobu Sakuma, Nobuo Katakura, Kazuo Shimozato, Katsunari Hiraba,