کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
4352248 | 1298101 | 2010 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Bioluminescence imaging of c-fos gene expression accompanying filial imprinting in the newly hatched chick brain
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب (عمومی)
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چکیده انگلیسی
Bioluminescence imaging is a powerful tool for examining gene expression in living animals. Previously, we reported that exogenous DNA could be successfully delivered into neurons in the newly hatched chick brain using electroporation. Here, we show the in vivo bioluminescence imaging of c-fos promoter activity and its upregulation, which is associated with filial imprinting. The upregulation of c-fos gene expression correlated with both the strength of the chicks’ approach activity to the training object and the acquisition of memory. The present technique should be a powerful tool for analyzing the time changes in neural activity of certain brain areas in real-time during memory formation, using brains of living animals.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience Research - Volume 67, Issue 2, June 2010, Pages 192–195
Journal: Neuroscience Research - Volume 67, Issue 2, June 2010, Pages 192–195
نویسندگان
Shinji Yamaguchi, Eiji Iikubo, Naoki Hirose, Takaaki Kitajima, Sachiko Katagiri, Ai Kawamori, Ikuko Fujii-Taira, Toshiya Matsushima, Koichi J. Homma,