کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4470609 1314434 2008 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Developmental and lactational exposure to environmentally relevant concentrations of dieldrin does not alter pregnancy outcome and mammary gland morphology in BALB/c mice
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
Developmental and lactational exposure to environmentally relevant concentrations of dieldrin does not alter pregnancy outcome and mammary gland morphology in BALB/c mice
چکیده انگلیسی
The objectives of this study were to: (1) determine the dosing range necessary to produce serum levels of dieldrin in mice representative of human body burdens; and (2) define the effect of developmental exposure to environmentally relevant concentrations of dieldrin on mammary gland development. Sexually mature female BALB/c mice (n=140) were randomly assigned to receive vehicle, 0.45, 2.25, 4.5, and 22.5 μg dieldrin/g body weight (BW)/day. Serum levels of dieldrin were quantified by gas chromatography in pooled samples (n=4/treatment group). Target levels of 10-30 ng/ml were achieved in 0.45 and 2.25 μg/g dose groups by the end of 2 weeks of treatment. Vehicle or dieldrin (0.45, 2.25, and 4.5 μg/g BW) was administered weekly to sexually mature female BALB/c mice (n=48) throughout mating, pregnancy, and lactation. Treatments had no effect on fertility parameters in dams or mammary gland morphology at sexual maturity. Developmental exposure to dieldrin has no effect on mammary gland development in aged BALB/c mice.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Environmental Research - Volume 108, Issue 1, September 2008, Pages 21-27
نویسندگان
, , , ,