کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4512604 1624833 2015 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Exploitation of amaranth oil fractions enriched in squalene for dual delivery of hydrophilic and lipophilic actives
ترجمه فارسی عنوان
بهره برداری از فراورده های نفتی آمارانت غنی شده در اسکالن برای تحویل دوگانه دارویی هیدروفیل و لیپوفیلی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک علوم زراعت و اصلاح نباتات
چکیده انگلیسی


• Co-encapsulation of water and lipid-soluble drugs in the same delivery system.
• Multiscaled squalene based-nanocarriers with nanoconfinements less than 15 nm.
• Co-encapsulation effect with values of about 90% for both kinds of drugs.
• Nanocarriers that assure a successful dual release of hydrophilic and lipophilic drugs.
• Antioxidant activity was observed to the extent of 98% scavenged free-oxygen radicals.

The study describes an ideal approach to increase the co-encapsulation of two water and lipid-soluble drugs in the same delivery system. The main purpose is represented by the exploitation of oil fractions isolated from amaranth seeds for the development of squalene-based nanocarriers able for a dual release of one antitumor drug, pemetrexed and one bio-flavonoid, hesperidin. The co-encapsulated nanocarriers presented unique nanoassembly morphology and showed excellent stability against aggregation. A delimited repartition of both actives, mainly in oily nanoconfinements of lipid nanocariers has been indicated by scanning calorimetry. The entrapment efficiency study revealed a great encapsulation effect with values reaching 94% for hesperidin and 89% for pemetrexed. These values are associated with a high ability of squalene-nanocarriers to capture free radicals. The greatest antioxidant activity was determined for nanocarriers that co-encapsulate 1.4% drugs, e.g., 97.3 and 98.2%. In vitro co-release tests demonstrated that pemetrexed and hesperidin were gradually released despite of their different lipophilicity. The most concentrated squalene fraction assures a slower release of both actives. The cumulative results showed that the applied strategy is a promising approach to improve the performance of medical treatments used to prevent and treat diseases associated with tumor and oxidative stress.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Industrial Crops and Products - Volume 77, 23 December 2015, Pages 342–352
نویسندگان
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