کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4558942 1330401 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Antiviral activity of herbal extracts against the hepatitis A virus
ترجمه فارسی عنوان
فعالیت ضد ویروسی عصاره های گیاهی در برابر ویروس هپاتیت A
کلمات کلیدی
ویروس هپاتیت A؛ ضد ویروس. شرکت درمان؛ ژاپونی توسکا؛ عصاره های گیاهی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم کشاورزی و بیولوژیک دانش تغذیه
چکیده انگلیسی


• Only co-treatment of herbal extract with HAV showed prominent anti-viral activity.
• The co-treatment of Alnus japonica extract at 50 μg/mL significantly reduced HAV by 3.43 log.
• The co-treatment of Artemisia annua extract at 50 μg/mL showed the 2.33 log reduction of HAV.
• Antiviral activity was not related with antioxidant of herbal extracts in this study.
• Alnus japonica extract could be applied to control HAV in food industry.

Herbal plants have long been used as traditional medicines to treat diseases caused by microbial pathogens. The hepatitis A virus (HAV) causes acute liver infection through the fecal–oral route. Although the antimicrobial activities of herbal extracts against bacterial and some viral pathogens have been extensively studied, their antiviral properties against HAV have not been investigated thus far. This study was designed to investigate the inhibitory effect of 16 herbal extracts against HAV. Significant inhibition of HAV was observed only when HAV was co-treated with extracts. Ten out of the 16 herbal extracts demonstrated significant virucidal activity against HAV. Alnus japonica extract at a concentration of 50 μg/mL reduced HAV titer by 3.43 ± 0.24 logs. Artemisia annua, Allium sativum, Allium fistulosum, and Agrimonia pilosa extracts showed 2.33 ± 0.43, 2.10 ± 0.41, 2.07 ± 0.60, and 2.03 ± 0.26-log reductions, respectively. Pleuropterus multiflorus, Eleutherococcus senticosus, Coriandrum sativum, Ginkgo biloba, and Torilis japonica extracts reduced HAV titer by 1.02 ± 0.21 to 1.90 ± 0.33 logs. Among the 10 herbal extracts, Alnus japonica extract was the most potent in inhibiting HAV without exhibiting cytotoxicity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Control - Volume 72, Part A, February 2017, Pages 9–13
نویسندگان
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