ReviewIntranasal oxytocin, social cognition and neurodevelopmental disorders: A meta-analysis

- 17 studies were included in the meta-analysis.
- Oxytocin had no significant effect on emotion recognition.
- Oxytocin had a small, significant effect on theory of mind.
- The effect did not differ according to the diagnosis, age of participants, dose or dose frequency.

Deficits in social cognition are pervasive and characteristic of neurodevelopmental disorders (NDDs). Clinical trials of intranasal oxytocin (IN-OT) to improve social cognition have yielded inconclusive results. The current study is a meta-analysis of randomized controlled trials (RCTs) considering the effect of IN-OT on social cognitive domains across a range of NDDs. Medline, PsychINFO and Scopus were searched for RCTs published through to July 25, 2017. Seventeen studies met inclusion criteria, comprising 466 participants with a NDD. Meta-analysis using a random-effects model, revealed that IN-OT had no significant effect on emotion recognition (Hedges' g = 0.08), a moderate but non-significant effect on empathy (Hedges' g = 0.49), and a small, significant effect on theory of mind (ToM) (Hedges' g = 0.21). Meta-regression indicated that the effect of IN-OT on social cognition was not moderated by the diagnosis or age of participants, or the dose or frequency of IN-OT administration. The results highlight a need for more well-designed RCTs, as it remains difficult to draw conclusions about the potential for IN-OT to improve social cognition in NDDs. The promise of IN-OT should be considered tentative.