کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
4934151 1363489 2018 8 صفحه PDF ندارد دانلود کنید
عنوان انگلیسی مقاله
Heart rate variability and salivary cortisol in very preterm children during school age
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی علوم غدد
پیش نمایش صفحه اول مقاله
Heart rate variability and salivary cortisol in very preterm children during school age
چکیده انگلیسی

•Children born very preterm had lower LF/HF ratio during wake and stage 2 sleep.•LF, Tot Pow, and LF/HF ratio were positively related with morning cortisol secretion.•The results indicate long-term ANS alterations after very preterm birth.•The results support the notion of a feedback system between the ANS and the HPA axis.

The autonomic nervous system (ANS) plays a major role in the human stress response and reflects physical and psychological adaptability to a changing environment. Long-term exposure to early life stressors may alter the function of the ANS. The present study examines differences in the ANS between children born very preterm and full-term as well as the association between the ANS and the hypothalamic-pituitary-adrenal (HPA) axis, the other main branch of the human stress system.Fifty-four healthy children born very preterm (<32nd gestational week) and 67 full-term children aged 7–12 years provided data for the present study. Polysomnography (PSG) assessments were obtained during a night at the children’s home in lying position at rest (wake) and during different sleep stages (stage 2 sleep, slow wave sleep, rapid-eye-movement sleep). Autonomic function was assessed by use of heart rate variability, specifically low frequency power (LF), high frequency power (HF), total spectral power (Tot Pow), and the LF/HF ratio. HPA axis activity was measured using salivary cortisol the next morning at awakening, 10, 20, and 30 min later.Children born very preterm had lower LF/HF ratio during wake and stage 2 sleep compared to full-term children. Moreover, higher LF, Tot Pow, and LF/HF ratio during wake, stage 2 sleep, and REM sleep were related to more post-awakening cortisol secretion.The present study provides evidence on long-term ANS alterations after very preterm birth. Moreover, findings suggest a relation between the ANS and the HPA axis and therefore support the notion of mutual feedback between the two human stress systems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Psychoneuroendocrinology - Volume 87, January 2018, Pages 27-34
نویسندگان
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