کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
4935514 1434222 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Microglial positron emission tomography (PET) imaging in epilepsy: Applications, opportunities and pitfalls
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Microglial positron emission tomography (PET) imaging in epilepsy: Applications, opportunities and pitfalls
چکیده انگلیسی
Neuroinflammation is increasingly implicated in epileptogenesis and epilepsy. Microglia are an important mediator of central nervous system inflammation, and the development of positron emission tomography (PET) radioligands which bind the Translocator Protein (TSPO), an outer mitochondrial membrane protein expressed by microglia, has enabled in vivo measurement of neuroinflammation. Here, we outline the principles and potential pitfalls of TSPO PET imaging in relation to epilepsy, and opportunities for using TSPO imaging as a biomarker for future anti-inflammatory based therapeutics in epilepsy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Seizure - Volume 44, January 2017, Pages 42-47
نویسندگان
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