کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5042427 | 1474387 | 2016 | 6 صفحه PDF | دانلود رایگان |
- Changes in EEG alpha activity have been related to clinical and experimental pain;
- Expectation of pain facilitation was associated with enhanced EEG alpha power;
- Enhanced low alpha power was related to pain catastrophizing;
- EEG markers of nocebo could be used to design neurofeedback interventions for pain.
Changes in EEG activity have been related to clinical and experimental pain. Expectation of a negative outcome can lead to pain enhancement (nocebo hyperalgesia) and can alter the response to therapeutic interventions. The present study characterizes EEG alteration related to pain facilitation by nocebo. Thirty healthy subjects were randomly assigned to the nocebo or control group. Five-minute EEG was recorded under: resting state, tonic innocuous heat and tonic noxious heat before and after the application of a sham inert cream to the non-dominant volar forearm combined with cognitive manipulation. The intensity and unpleasantness of heat-induced pain increased after cognitive manipulation in the nocebo group compared to control and was associated with enhanced low alpha (8-10Â Hz) activity. However, changes in alpha activity were predicted by catastrophizing but not by pain intensity or unpleasantness, which suggest that low alpha power might reflect brain activity related to negative cognitive-affective responses to pain.
Journal: International Journal of Psychophysiology - Volume 109, November 2016, Pages 147-152